Revealing the decrease of indoleamine 2,3-dioxygenase as a major constituent for B cells survival post-mesenchymal stem cells co-cultured with peripheral blood mononuclear cell (PBMC) of systemic lupus erythematosus (SLE) patients
Aim Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by inhibiting indoleamine 2,3-dioxygenase (IDO), and increasing regulatory T cells (Treg) to control innate and adaptive immune cells. However, the interaction and mechanism regarding IDO and B cells in the co-culture of ...
By Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Iffan Alif, Nur Dina Amalina, Nelva Karmila Jusuf, Imam Budi Putra
In vitro regulation of IL-6 and TGF-ß by mesenchymal stem cells in systemic lupus erythematosus patients
Aim To analyse the ability of mesenchymal stem cells (MSCs) to regulate interleukin 6 (IL-6) and transforming growth factor (TGF-β) expression in vitro under co-culture conditions in human systemic lupus erythematosus (SLE). MethodThis study used a post-test group design that used peripheral blood mononuclear cells (PBMCs) from SLE patients at...
By Dewi Masyithah Darlan, Delfitri Munir, Nelva Karmila Jusuf, Agung Putra, Riyadh Ikhsan, Iffan Alif