Aim To investigate effect of bay leaf extract in endothelial integrity, observed by vascular endothelial growth factor (VEGF) level, VEGF and CD31 expression. Methods Thirty-two acute coronary syndrome surgery-induced Wistar Rats (Rattus novergicus) were divided into 16 bay leaf extract (treatment) groups and 16 control groups, sacrificed on day 1,...

By Refli Hasan, Siregar Gontar Alamsyah, Dharma Lindarto

Aim To determine the effect of roselle (Hibiscus sabdariffa) petals in dextran sodium sulfate (DSS)-induced colitis model by measuring pro-inflammatory cytokines expressions (IL-6, and TNF-α), anti-inflammatory cytokine expression (IL-10) and histological colitis inflammation score (HCIS). Methods This study was conducted in two phases. For t...

By Masrul Lubis, Gontar Alamsyah Siregar, Hakim Bangun, Syafruddin Ilyas

Aim To investigate the effects of interleukin-8 (IL-8)-251 T/A and +781 C/T polymorphism on the risk of Helicobacter pyloriinfection gastritis in children, and the IL-8 level of children with or without gastritis H. pylori infection according to polymorphism. Methods This prospective, case control clinical study included 64 children 2-18 years old....

By Dr Supriatmo, Gontar Alamsyah Siregar, Iqbal Pahlevi Adeputra Nasution, Oke Rina Ramayani

Aim To study the anti-inflammatory effect of bay leaf on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model with myocardial infarction. Methods In the first phase, results of pathological examination and biochemical assay were compared between rats with and without induction of myocardial infarction. In the second ph...

By Refli Hasan, Dharma Lindarto, Gontar Alamsyah Siregar, Zulfikri Mukhtar