Anti-fibrotic effect of intravenous umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection in experimental rats induced liver fibrosis
Aim To investigate the effect of umbilical cord-derived mesenchymal stem cells (UC-MSCs) administration among liverfibrosis experimental rat model via the regulation of angiotensin II type 1 receptor (AT1R) and platelet-derived growth factor-β (PDGF-β) due to their therapeutic potential to replace liver transplantation for advanced liver ...
By Taufik Sungkar, Agung Putra, Dharma Lindarto, Rosita Juwita Sembiring
The effect of bay leaf extract (Syzygium polyanthum) on vascular endothelial growth factor (VEGF) and CD31 (PECAM-1) expression in acute coronary syndrome
Aim To investigate effect of bay leaf extract in endothelial integrity, observed by vascular endothelial growth factor (VEGF) level, VEGF and CD31 expression. Methods Thirty-two acute coronary syndrome surgery-induced Wistar Rats (Rattus novergicus) were divided into 16 bay leaf extract (treatment) groups and 16 control groups, sacrificed on day 1,...
By Refli Hasan, Siregar Gontar Alamsyah, Dharma Lindarto
Association between CD133 expression and clinicopathological profile in colorectal cancer
Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients.Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik GeneralHospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from C...
By Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf
Association of endothelial nitric oxide synthase gene (G894T) polymorphism and hypertension in diabetic Bataknese patients
Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.Methods A hospital-based, case control study (hypertensive and normotensive diabetic patient) was conducted. Genotyping ofeNOS gene (G894T) was done using polymerase chain reactionrestriction fragm...
By Jelita Siregar, Ratna Akbari Ganie, Dharma Lindarto, Erna Mutiara, Delfitri Munir
The effect of bay leaf extract Syzygium polyanthum (Wight) Walp. on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model of myocardial infarction
Aim To study the anti-inflammatory effect of bay leaf on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model with myocardial infarction. Methods In the first phase, results of pathological examination and biochemical assay were compared between rats with and without induction of myocardial infarction. In the second ph...
By Refli Hasan, Dharma Lindarto, Gontar Alamsyah Siregar, Zulfikri Mukhtar