Revealing the decrease of indoleamine 2,3-dioxygenase as a major constituent for B cells survival post-mesenchymal stem cells co-cultured with peripheral blood mononuclear cell (PBMC) of systemic lupus erythematosus (SLE) patients
Aim Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by inhibiting indoleamine 2,3-dioxygenase (IDO), and increasing regulatory T cells (Treg) to control innate and adaptive immune cells. However, the interaction and mechanism regarding IDO and B cells in the co-culture of ...
By Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Iffan Alif, Nur Dina Amalina, Nelva Karmila Jusuf, Imam Budi Putra
Mesenchymal stem cells under hypoxia condition inhibit peritoneal adhesion by suppressing the prolonged release of interleukin-6
Aim To investigate the role of hypoxia-preconditioned mesenchymal stem cells (H-MSCs) in preventing peritoneal adhesionby regulating IL-6 at days 6 and 12.Methods Twenty-four PAs rat model weighing 250 g to 300 g were randomly allocated into 4 groups: sham (Sh), control (C),H-MSCs treatment group at dose 1.5 x 106 (T1) and 3 x 106 (T2). To in...
By Adi Muradi Muhar, Agung Putra, Vito Mahendra Ekasaputra, Dewi Masyithah Darlan, Desiree Anggia Paramita, Iqbal Pahlevi Adeputra Nasution
Prevalence of Cryptosporidium spp. and Blastocystis hominis in faecal samples among diarrheic HIV patients in Medan, Indonesia
Aim To investigate the prevalence of Cryptosporidium sp. and B. hominis among human immunodeficiency virus (HIV) positive patients in two different outpatient clinics, Haji Adam Malik General Hospital and Primary Care Centre of Padang Bulan, Medan, Indonesia, between two interval periods.Method Cryptosporidium spp. microscopic examination, as well ...
By Hemma Yulfi, Muhammad Fakhrur Rozi, Yunilda Andriyani, Dewi Masyithah Darlan
In vitro regulation of IL-6 and TGF-ß by mesenchymal stem cells in systemic lupus erythematosus patients
Aim To analyse the ability of mesenchymal stem cells (MSCs) to regulate interleukin 6 (IL-6) and transforming growth factor (TGF-β) expression in vitro under co-culture conditions in human systemic lupus erythematosus (SLE). MethodThis study used a post-test group design that used peripheral blood mononuclear cells (PBMCs) from SLE patients at...
By Dewi Masyithah Darlan, Delfitri Munir, Nelva Karmila Jusuf, Agung Putra, Riyadh Ikhsan, Iffan Alif