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Review paper
Received: 26.05.2023. >> Accepted: 06.10.2023. >> Published: 06.11.2023. Biochemistry
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https://doi.org/10.17392/1633-23

Does SarsCoV-2 infection really cause damage to retinal microcirculation in mild cases of COVID-19?

By
Adisa Pilavdžić Orcid logo ,
Adisa Pilavdžić
Contact Adisa Pilavdžić

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Suzana Pavljašević ,
Suzana Pavljašević

Eye Polyclinic Health Centre , Tuzla , Bosnia and Herzegovina

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Amra Nadarević Vodenčarević ,
Amra Nadarević Vodenčarević

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Anis Međedović ,
Anis Međedović

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Meliha Halilbašić ,
Meliha Halilbašić

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Alma Čičkušić ,
Alma Čičkušić

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Nejra Hodžić ,
Nejra Hodžić

Department of Ophthalmology , Plava Medical Group Tuzla , Tuzla , Bosnia and Herzegovina

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Sumeja Terzić ,
Sumeja Terzić

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Azra Šmigalović ,
Azra Šmigalović

Eye Polyclinic , Health Centre Kalesija , Kalesija , Bosnia and Herzegovina

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Sanela Muhović
Sanela Muhović

Eye Clinic, University Clinical Centre Tuzla , Tuzla , Bosnia and Herzegovina

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Abstract

Aim
To evaluate changes of retinal microcirculation in mild cases of recovered COVID-19 patients at least three months after the infection by optical coherence tomography angiography (OCTA) non-invasive method.
Methods
In this prospective cross-sectional study, 50 right eyes of 50 recovered COVID-19 patients were compared with 50 right
eyes of age and gender-matched healthy controls. After the complete ophthalmological examination, all participants underwent OCTA measurements (RTVue XR Avanti, Optovue, Fremont, CA, USA).
Results
The time between the initial onset of symptoms, and ophthalmologic examination was 479.20 ±197.10 (126-754)
days. Findings of ophthalmic examination of all eyes of the recovered COVID-19 patients were within normal range. Significantly reduced superficial (p=0.046) and deep (p=0.044) macular vessel density (VD) in foveal region in the eyes of the recovered COVID-19 patients was found compared with healthy controls. Significantly enlarged foveal avascular zone (FAZ) area and perimeter in the eyes of the recovered COVID-19 patients (p<0.001) were found too.
Conclusion
Recovered COVID-19 patients have impaired retinal microcirculation, which can be a cause of the development of retinal vascular diseases.

Keywords:

coronavirus,
OCT angiography,
retina,
vascular density

References

1.
Abid A, Khan MA, Lee B, White A, Carnt N, Arshad S, et al. Ocular distribution of the renin-angiotensin-aldosterone system in the context of the SARS-CoV-2 pandemic. J Renin Angiotensin Aldosterone Syst. 2022;2022(9970922).
2.
Xu B, Zhang J, Zhang Y, Cheng Y, Huang Q. Transient increase in patient numbers with “acute macular neuroretinopathy” post SARS-CoV-2 infection—case series during the first surge of infection in December 2022. J Inflamm Res. 2023;16:2763–71.
3.
Zhang YH, Zhang YH, Dong XF, Hao QQ, Zhou XM, Yu QT, et al. ACE2 and Ang-(1-7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response. Inflamm Res. 2015;64:253–60.
4.
T. K, Y. O, S. I, H. O, T. TKK, Y. O, et al. Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. Int J Inflam. 2012;2012(581695).
5.
Hohberger B, Ganslmayer M, Lucio M, Kruse F, Hoffmanns J, Moritz M, et al. Retinal microcirculation as a correlate of a systemic capillary impairment after severe acute respiratory syndrome coronavirus 2 infection.
6.
A NB, A D, F K, H G, Z H, SE M, et al. Retinal findings of COVID-19 patients using ocular coherence tomography angiography two to three months after infection: Ocular appearance recovered COVID-19 patient. Photodiagnosis Photodyn Ther. 2022;38(102726).
7.
Guemes-Villahoz N, Burgos-Blasco B, Vidal-Villegas B, Donate-López J, Muela MH, López-Guajardo L, et al. Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events using optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2021;259:2243–9.
8.
Sodhi PK, Arora R, Kumar S, Jaisingh K, Archana TR, Rao KC, et al. Optical coherence tomography angiography parameters of the retina in SARS-CoV-2 recovered subjects. Cureus. 2023;15:e33548.
9.
Wang S, Wang J, Hu J, Wang N. Retinal microvascular impairment in COVID-19 patients: a metaanalysis. Immun Inflamm Dis. 2022;10:e619.
10.
A YÇ, O K, D U. Evaluation of retinal microvascular impairment after COVID-19 and its clinical correlates using optical coherence tomography angiography. Turk J Ophthalmol. 2022;52:324–30.
11.
Jevnikar K, Meglič A, Lapajne L, Logar M, Vidovič Valentinčič N, Globočnik Petrovič M, et al. The impact of acute COVID-19 on the retinal microvasculature assessed with multimodal imaging. Graefes Arch Clin Exp Ophthalmol. 2023;261:1115–25.
12.
Landecho MF, Yuste G, E S, P Q, J A, AB GL, et al. COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease? J Intern Med. 2021;289:116–20.
13.
Chiosi F, Campagna G, Rinaldi M, Manzi G, dell’Omo R, Fiorentino G, et al. Optical coherence tomography angiography analysis of vessel density indices in early post-COVID-19 patients.
14.
S BG, D A, B A, F T, X GS, A SM, et al. Persistent reduction of retinal microvascular vessel density in patients with moderate and severe COVID-19 disease. BMJ Open Ophthalmol. 2022;7:e000867.
15.
Kal M, Winiarczyk M, Mackiewicz J, Odrobina D, Cieśla E, Płatkowska-Adamska B, et al. The effect of reduced oxygen saturation on retinal microvascularization in COVID-19 patients with bilateral pneumonia based on optical coherence tomography study. J Pers Med. 2022;12(1824).
16.
Gül FC, Timurkaan ES. Evaluation of choroidal thickness with OCT in COVID-19 patients with high D-dimer levels. Sci Rep. 2022;12(16826).
17.
Cennamo G, Reibaldi M, Montorio D, D’Andrea L, Fallico M, Triassi M. Optical coherence tomography angiography features in post-COVID-19 pneumonia patients: a pilot study. J Ophthalmol. 2021;227:182–90.
18.
Hazar L, Karahan M, Vural E, Ava S, Erdem S, Dursun ME, et al. Macular vessel density in patients recovered from COVID 19. Photodiagnosis Photodyn Ther. 2021;34(102267).
19.
González-Zamora J, Bilbao-Malavé V, Gándara E, Casablanca-Piñera A, Boquera-Ventosa C, Landecho MF, et al. Retinal microvascular impairment in COVID-19 bilateral pneumonia assessed by optical coherence tomography angiography. Biomedicines. 2021;9(247).
20.
Abrishami M, Emamverdian Z, Shoeibi N, Omidtabrizi A, Daneshvar R, Saeidi Rezvani T, et al. Optical coherence tomography angiography analysis of the retina in patients recovered from COVID 19: a casecontrol study. Can J Ophthalmol. 2021;56:24–30.
21.
Kalaw FGP, Warter A, Cavichini M, Knight D, Li A, Deussen D, et al. Retinal tissue and microvasculature loss in COVID-19 infection. Sci Rep. 2023;13(5100).
22.
Zapata MÁ, Banderas García S, Sánchez-Moltalvá A, Falcó A, Otero-Romero S, Arcos G, et al. Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity. Br J Ophthalmol. 2022;106:559–63.
23.
Savastano MC, Gambini G, Cozzupoli GM, Crincoli E, Savastano A, Vico U, et al. Retinal capillary involvement in early post-COVID-19 patients: a healthy controlled study. Graefes Arch Clin Exp Ophthalmol. 2021;259:2157–65.

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