Aim To systematically review the scientific evidence of biomarker validity, reliability, specificity and sensitivity in identifying malnutrition in the elderly. Methods Peer-reviewed journals were searched using PUBMED and EBSCO from January 1998 to April 2018. The articles included description of the association between malnutrition blood biomarkers and validated nutritional status assessment instruments and studies were conducted among community-dwelling elderly or nursing home residents. Results The research strategy identified a total of 293 studies. This literature review picked out seven articles for follow-up evaluation. A total of sixteen blood biomarkers were identified. Six studies found a significant association between the nutritional assessment score and albumin level. Conclusion Combining serum concentrations of malnutrition biomarkers with nutritional status assessment tools has a great potential in identifying the risk of malnutrition in the elderly, while also increasing sensitivity and specificity.
Macintosh C, Morley J, Chapman I. The anorexia of aging. Nutrition. 2000;983–5.
2.
Tsutsumi R, Tsutsumi Y, Horikawa Y, Takehisa Y, Hosaka T, Harada N, et al. Decline in anthropometric evaluation predicts a poor prognosis in geriatric patients. Asia Pac J Clin Nutr. 2012;44–51.
3.
Ahmed T, Haboubi N. Assessment and management of nutrition in older people and its importance to health. Clin Interv Aging. 2010;207–16.
4.
Mion L, Mcdowell J, Heaney L. Nutritional assessment of the elderly in the ambulatory care setting. Nurse Pract Forum. 1994;46–51.
5.
Bedogni G, Battistini N, Severi S, Borghi A. The physiological bases of the assessment of nutritional status. Clin Diet. 1996;141–6.
6.
Račić M, Ivković N, Kusmuk S. Screening of nutritional status among elderly people at family medicine. Acta Med Croatica. 2015;347–56.
7.
Hamirudin A, Charlton K, Walton K, Bonney A, Albert G, Hodgkins A, et al. Is nutrition screening of older patients feasible? Austr Fam Physician. 2013;321–6.
8.
Moher D, Liberati A, Tetzlaf J, Altman D, Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;2535.
9.
Hammick M, Dornan T, Steinert Y. Conducting a best evidence systematic review. Part 1: from idea to data coding. BEME Guide No. 13. Med Teach. 2010;3–15.
10.
Abd-El-Gawad W, Abou-Hashem R, Maraghy E, Amin M, G. The validity of Geriatric Nutrition Risk Index: simple tool for prediction of nutritionalrelated complication of hospitalized elderly patients. Clin Nutr. 2014;1108–16.
11.
Htun N, Ishikawa -Takata K, Kuroda A, Tanaka T, Kikutani T, Obuchi S, et al. Screening for malnutrition in community dwelling older Japanese: preliminary development and evaluation of the Japanese nutritional risk screening tool (nrst). J Nutr Health Aging. 2016;114–20.
12.
Kuzuya M, Kanda S, Koike T, Suyuki Y, Satake S, Iguchi A. Evaluation of Mini-Nutritional Assessment for Japanese frail elderly. Nutrition. 2005;498–503.
13.
Christensson L, Unossonm, Ek A. Evaluation of nutritional assessment techniques in elderly people newly admitted to municipal care. Eur J Clin Nutr. 2002;810–8.
14.
Kuzuya M, Izawa S, Enoki H, Okada K, Iguchi A. Is serum albumin a good marker for malnutrition in the physically impaired elderly? Clin Nutr. 2007;84–90.
15.
Zhou J, Wang M, Wang H, Chi. Comparison of two nutrition assessment tools in surgical elderly inpatients in Northern China. Nutr J. 2015;68.
16.
Bouillanne O, Golmard J, Coussieu C, Noel M, Durand D, Piette F, et al. Leptin a new biological marker for evaluating malnutrition in elderly patients. Eur J Clin Nutr. 2007;647–54.
17.
Smith D. Anemia in the elderly. Am Fam Physician. 2000;1565–72.
18.
Omran M, Morley J. Assessment of protein energy malnutrition in older persons, Part II: Laboratory evaluation. Nutrition. 2000;131–40.
19.
Zhang Z, Pereira S, Luo M, Matheson E. Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis. Nutrients. 2017;829.
20.
Barchel D, Almoznino-Sarafian D, Shteinshnaider M, Tzur I, Cohen N, Gorelik O. Clinical characteristics and prognostic significance of serum albumin changes in an internal medicine ward. Eur J Intern Med. 2013;772–8.
21.
París S, García A, Gómez-Candela J, Burgos C, Martín R, Matía Á, et al. Malnutrition prevalence in hospitalized elderly diabetic patients. Nutr Hosp. 2013;592–9.
22.
Schiesser M, Kirchhoff P, Muller M, Schafer M, Clavien P. The correlation of nutrition risk index, nutrition risk score, and bioimpedance analysis with postoperative complications in patients undergoing gastrointestinal surgery. Surgery. 2009;519–26.
23.
Soeters P, Reijven P, Van Bokhorst-De Van Der Schueren M, Schols J, Halfens R, Meijers J, et al. A rational approach to nutritional assessment. Clin Nutr. 2008;706–16.
24.
Shum N, Hui W, Chu F, Chai J, Chow T. Prevalence of malnutrition and risk factors in geriatric patients of a convalescent and rehabilitation hospital. Hong Kong Med J. 2005;234–42.
25.
Chevalier S, Saoud F, Gray-Donald K, Morais J. The physical functional capacity of frail elderly persons undergoing ambulatory rehabilitation is related to their nutritional status. J Nutr Health Aging. 2008;721–6.
26.
Benigni I, Devos P, Rofidal T, Seguy D. The CP-MST, a malnutrition screening tool for institutionalized adult cerebral palsy patients. Clin Nutr. 2011;769–73.
27.
Wikby K, Ek A, Christensson L. Nutritional status in elderly people admitted to community residential homes: comparisons between two cohorts. J Nutr Health Aging. 2006;232–8.
28.
Devoto G, Gallo F, Marchello C, Racchi O, Garbarini R, Bonassi S, et al. Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients. Clin Chem. 2006;2281–5.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
,
