Aim To determine the spectrum of causative agent of prosthetic joint infections in orthopaedics. Methods In the group of 50 patients with periprosthetic infection the results of microbiological analysis of minimally two samples gained intraoperatively were analysed. Results The only pathogen in the group of acute infection was Staphylococcus (S.) aureus. In case of delayed infection the most frequent pathogen was also S. aureus and in case of late infection it was coagulase-negative staphylococcus. Conclusion A better understanding of the most common agents responsible for prosthetic joint infection helps us to properly prepare the patient (by eradicating of potential focus) with adequate antibiotic prophylaxis and early treatment of suspected infections to further reduce the incidence of infectious complications in orthopaedics. It is important to bear in mind that patients who have undergone total joint replacement have a risk of infection for the rest of their lives.
JL DP, R P. Infection associated with prosthetic joints. Vol. 361, N Engl J Med. 2009. p. 787–94.
2.
Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J. Infection burden for hip and knee arthroplasty in the United States. Vol. 23, J Arthroplasty. 2008. p. 984–91.
3.
Tsaras G, Osmon DR, Mabry T, Lahr B, Sauveur J, Yawn B, et al.
4.
Incidence, secular trends, and outcomes of prosthetic joint infection: a population-based study, Olmsted County. Vol. 33. 1969.
5.
Zimmerli W. Infection and musculoskeletal conditions: prosthetic-joint-associated infections. Vol. 20, Best Pract Res Clin Rheumatol. 2006. p. 1045–63.
6.
RH F, DR N, DM I, Scoy RE. Deep wound sepsis following total hip arthroplasty. Washington JA 2nd, Coventry MB. Vol. 59, J Bone Joint Surg Am. 1977. p. 847–55.
7.
Sogawa K, Watanabe M, Sato K, Segawa S, Ischii C, Miyabe A, et al. Use of the MALDI BioTyper system with MALDI-TOF mass spectrometry for rapid identification of microorganisms. Vol. 400, Anal Bioanal Chem. 2011. p. 1905–11.
8.
Manukumar HM, Umesha S. MALDI-TOF-MS based identification and molecular characterization of food associated methicillin-resistant Staphylococcus aureus. Vol. 7, Sci Rep. 2017.
Oh AC, Lee JK, Lee HN, Hong YJ, Chang YH, Hong SI, et al. Clinical utility of the Xpert MRSA assay for early detection of methicillin-resistant Staphylococcus aureus. Vol. 7, Mol Med Rep. 2013. p. 11–5.
11.
Tande AJ, Patel R. Prosthetic joint infection. Vol. 27, Clin Microbiol Rev. 2014. p. 302–45.
12.
Song Z, Borgwardt L, Høiby N, Wu H, Sørensen TS, Borgwardt A. Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms. Vol. 5, Orthop Rev. 2013. p. 65–71.
13.
Wang FD, Wang YP, Chen CF, Chen HP. The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: a 13 years’ experience from a tertiary medical center in taiwan. Vol. 51, J Microbiol Immunol Infect. 2018. p. 717–22.
14.
Benito N, Franco M, Ribera AM, Soriano A, Rodríguez-Pardo D, Sorlí L, et al. Time trends in the etiology of prosthetic joint infections: A multicenter cohort study. Vol. 34, Clin Microbiol Infect. 2016. p. 45–9.
15.
Pulido L, Ghanem E, Joshi A, Purtill JJ, Parvizi J. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Vol. 466, Clin Orthop Relat Res. 2008. p. 1710–5.
16.
Li ZL, Hou YF, Zhang BQ, Chen YF, Wang G, Wank K, et al. Identifying common pathogens in periprosthetic joint infection and testing drug-resistance rate for different antibiotics: a prospective, single centre study in Beijing. Vol. 10, Ortop Surg. 2018. p. 235–40.
17.
Parvizi J, Fassihi SC, Enayatollahi MA. Diagnosis of periprosthetic joint infection following hip and knee arthroplasty. Vol. 47, Orthop Clin North Am. 2016. p. 505–15.
18.
Franceschini V, Chillemi C. Periprosthetic shoulder infection. Vol. 7, Open Orthop J. 2013. p. 243–9.
19.
Spangehl MJ, Masri BA, O’connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. Vol. 81, J Bone Joint Surg Am. 2015. p. 672–83.
20.
Phillips JE, Crane TP, Noy M, Elliott TS, Grimer RJ. The incidence of deep prosthetic infections in a specialist orthopaedic hospital: a 15-year prospective survey. Vol. 88, J Bone Joint Surg Br. 2006. p. 943–8.
21.
Becker K, Heilmann CH, Peters G. Coagulase-negative staphylococci. Vol. 27, Clin Microbiol Rev. 2014. p. 870–926.
22.
Donlan RM. Biofilms: microbial life on surfaces. Vol. 9, Emerg Infect Dis. 2014. p. 881–90.
23.
Shahi A, Parvizi J. Prevention of periprosthetic joint infection. Vol. 3, Arch Bone Jt Surg. 2015. p. 72–81.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
,
