,
Obstetrics and Gynaecology Department, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Obstetrics and Gynaecology Department,, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Pharmacology Department, School of Medicine, Indonesia
Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara,
Clinical Pathology Department, School of Medicine, Universitas Sumatera Utara, Indonesia
Obstetrics and Gynaecology Department, School of Medicine, Universitas Sriwijaya, Indonesia
Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia
Microbiology Department, School of Medicine, Universitas Sumatera Utara, Indonesia
Aim
Vulvovaginal candidiasis (VVC) is a disease mostly caused by Candida albicans and affects the quality of life of women especially in the form of chronic recurrent vulvovaginal candidiasis (RVVC). Nigella sativa is known to have several effects such as antimicrobial, anti-inflammatory, immune stimulation and anticancer properties. The aim of this study was to evaluate the effect of Nigella sativa on vulvovaginal candidiasis.
Methods
This study is a true experimental design, we used 28 Wistar strain rats divided into 4 groups, all groups were conditioned in a pseudoestrus state. Candida albicans was inoculated into the rats' vagina for 3 consecutive days. All groups were observed every 24 hours, 48 hours and 72 hours to evaluate the number of Candida albicans colonies, IgG and IgM anti Candida. Results
After administration of intervention, there was a significant difference in the amount of fungal colonization after the treatment in each group (p<0.001). There was no significant difference in the effectiveness of Nigella sativa and fluconazole in supressing Candida albicans colonies after 72 hours (p=0.101). The administration of Nigella sativa showed a significant difference in the increase in IgM levels compared to the others group (p<0.001), while the IgG level did not show a significant difference (p=0.423).
Conclusion
Nigella sativa provides a therapeutic effect by decreasing the number of fungal colonies and increasing IgM levels.
Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. 
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.