Aim To explore the possibility of C-reactive protein (CRP) and haemoglobin (Hb) in prediction and risk assessment of acute kidney injury (AKI) among preterm newborns. This is believed to be closely related to the incidences of AKI, and could be the most affordable in early detection of AKI. Methods A case control study was carried out at Dr Hasan Sadikin Hospital in Bandung with a total of 112 preterms divided into two groups: with and without AKI based on the neonatal KDIGO (Kidney Disease: Improving Global Outcomes). CRP and creatinine serum were measured within 6 hours and at 72-96 hours after birth. The routine blood count included haemoglobin, haematocrit, leucocyte, and thrombocyte in the first 24 hours of life. Results CRP increase was the most influential factor for AKI with sensitivity of 80.6% and specificity of 60.2%. An increase in CRP >0.04 had an aOR (95% CI) of 5.64 (1.89–16.84). Haemoglobin <14.5 g/dL had slightly increased aOR (95% CI) of 1.65 (1.05- 8.63) Conclusion CRP increases >0.04 and level Hb <14.5 g/dL showed acceptable as an early warning for AKI in preterm newborns.
Viswanathan S, Mhanna M. Acute Kidney Injury in Premature Infants. J Clin Pediatr. 2013;
2.
Luyckx V. Preterm birth and its impact on renal health. Semin Nephrol. 2017;311–9.
3.
Bruel A, Rozé JC, Quere MP, Flamant C, Boivin M, Roussey-Kesler G, et al. Renal outcome in children born preterm with neonatal acute renal failure: IRENEO-a prospective controlled study. Pediatr Nephrol. 2016;2365–73.
4.
Stojanovic V, Barisie N, Milanovic B, Doronjski A. Acute kidney injury in preterm infants admitted to a neonatal intensive care unit. Pediatr Nephrol. 2014;2213–20.
5.
Black M, Sutherland M, Gubhaju L. Basic Nephrology and Acute Kidney Injury. 1st ed. 2011;61–88.
6.
Momtaz H, Sabzehei M, Rasuli B, Torabian S. The main etiologies of acute Kidney injury in the newborns hospitalized in the neonatal intensive care unit. J Clin Neonatol. 2014;99.
7.
Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. Clin Biochem Rev. 2016;85–97.
8.
Ottonello G, Dessì A, Neroni P, Trudu M, Manus D, Fanos V. Acute kidney injury in neonatal age. J Pediatr Neonatal Individ Med. 2014;2–5.
9.
Durkan A, Alexander R. Acute kidney injury post neonatal asphyxia. J Pediatr. 2011;(Suppl 2):29–33.
10.
Kdigo. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Acute Kidney Injury. J Int Soc Nephrol. 2012;
11.
Marenzy G, Consentino N, Bartorelli A. Acute kidney injury in patients with acute coronary syndromes. Heart. 2015;1778–85.
12.
Ghobrial E, Elhouchi S, Eltatawy S, Beshara L. Risk factors associated with acute kidney injury in newborn. Saudi J Kidney Dis Transpl. 2018;81–7.
13.
Bullen B, Jones N, Holzman C, Tian Y, Senagore P, Thorsen P, et al. C-reactive protein and preterm delivery. Reprod Sci. 2013;715–22.
14.
Asada N. Tubular immaturity causes erythropoietindeficiency anemia of prematurity in preterm neonates. Sci Rep. 2018;4448.
15.
Kates E, Kate. Anemia and polycythemia in the newborn. Pediatr Rev. 2007;33–4.
16.
Siller L, Slambrouck C. Lapping-carr G. Neonatal thrombocytopenia: etiology and diagnosis. Pediatr Ann. 2015;175–80.
17.
Oncel M, Canpolat F, Arayici S, Dizdar E, Uras N, Oguz S. Urinary markers of acute kidney injury in newborns with perinatal asphyxia. Renal Failure. 2016;882–8.
18.
Libório A, Branco K. Torres De Melo Bezerra C. Acute kidney injury in neonates: From urine output to new biomarkers. Biomed Res Int. 2014;601568.
19.
Tang Y, Kwong-Mak S, Xu A, Yao LH. Role of C-reactive protein in the pathogenesis of acute kidney injury. Nephrology (Carlton). 2018;(Suppl 4):50–2.
20.
Nickavar A, Khosravi N, Mazouri A. Predictive Factors for Acute Renal Failure in Neonates with Septicemia. Arch Pediatr Infect Dis. 2017;61627.
21.
Cosentino N, Genovese S, Campodonico J, Bonomi A, Lucci C, Milazzo V, et al. High-sensitivity c-reactive protein and acute kidney injury in patients with acute myocardial infarction: a prospective observational study. J Clin Med. 2019;2192.
22.
Pageus M, Mccrory M, Zarjou A, Szalai A. C-reactive protein exacerbates renal ischemia reperfusion injury (P4021). J Immunol. 2013;131–42.
23.
Stritzke A, Thomas S, Amin H, Fusch C, Abhay L. Renal consequences of preterm birth. Mol Cel Pediatr. 2017;1–9.
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