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Review paper

Correlation of demographic, histological and molecular characteristics and clinical course of the disease in patients with lung adenocarcinoma

By
Lora Novaković Lacković Orcid logo ,
Lora Novaković Lacković
Contact Lora Novaković Lacković

Clinic for Lung Diseases of the University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

Ljilja Latinović Tadić ,
Ljilja Latinović Tadić

Department of Pathology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

Mirko Stanetić ,
Mirko Stanetić

Clinic for Lung Diseases of the University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

Nataša Tanasković ,
Nataša Tanasković

Clinic for Lung Diseases of the University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

Slavica Marić ,
Slavica Marić

International Medical Centre of Banja Luka, Banja Luka, Bosnia and Herzegovina

Marko Lacković
Marko Lacković

University of Banja Luka, Banja Luka, Bosnia and Herzegovina

Abstract

Aim
Retrospective analysis of disease clinical course with a purpose of defining potential prognostic parameters which are essential for optimal target therapy.
Methods
The study involved 29 patients with histologically confirmed lung adenocarcinoma and existing epidermal growth factor receptor (EGFR) mutations, which are treated by tyrosine kinase inhibitors (TKI).
Results
Allegations of a larger prevalence in women and non-smokers were found. The study confirmed dominance of mutations on exon 19 and exon 21. Usefulness of the treatment with erlotinib in terms of increasing survival time was evident. Median survival of patients in the survey sample was 14.5 months. Median survival in relation to gender or smoking status did not show statistical significance.
Conclusion
Considering obtained results, we have confirmed that patients with advanced lung adenocarcinoma and present mutations of epidermal growth factor receptor, who had been treated with first generation TKI, had median survival time of over a year.

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