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Review paper

Therapeutic efficacy and toxicity of bolus application of chemotherapy protocol in the treatment of metastatic colorectal cancer

By
Ibrahim Šišić ,
Ibrahim Šišić
Contact Ibrahim Šišić

Department of Oncology, Hematology and Radiotherapy, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina

Belma Pojskić ,
Belma Pojskić

Department of Internal Diseases, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina

Alma Mekić-Abazović ,
Alma Mekić-Abazović

Department of Oncology, Hematology and Radiotherapy, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina

Vladimir Kovčin
Vladimir Kovčin

Department of Oncology, Clinical Hospital Centre Bežanijska kosa Beograd , Beograd , Serbia

Abstract

Aim
To compare efficacy and toxicity of bolus application of chemotherapy protocol, oxaliplatin, fluorouracil (bolus), leucovorin
(folfox) between two groups of patients in the therapy of metastatic colorectal carcinoma (mCRC).
Methods
A total of 63 patients were treated for mCRC in the period January 2009 – January 2010 at the Department of Oncology
of the Cantonal Hospital Zenica, Bosnia and Herzegovina (first group, 30 patients) and at the Department of Oncology of the Clinical Hospital Centre Bežanijska kosa in Belgrade, Serbia, in the period January 2005 – January 2006 (second group, 33 patients). The patients were treated according the same protocol, i.v. bolus infusion, but in different day intervals (D), 1, 8, 15/28 days or D1-D5/28 days, respectively. In all patients the following factors were analyzed: tumor response, overall survival (OS), progression free survival, hematological and non-hematological toxicity .
Results
Colon was the primary localization in almost two thirds of patients. There was no statistically significant difference between
the groups according to the age, hematological and non-hematological toxicity, as well as in achieved OS. Progression free survival expressed in months was in average 5 months though with a large range between minimal and maximal survival time.
Conclusion
Both groups have shown equivalent efficacy to applied chemotherapy protocols. Overall survival in the two groups
matched data from the literature. Further research should confirm success of the combination of chemotherapy protocols and their combination with the biological therapy.

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