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Review paper
Published: 24.08.2018. Biochemistry
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https://doi.org/10.17392/990-19

The serum triglyceride to high-density lipoprotein (HDL) ratio in patients with acute coronary syndrome with and without renal dysfunction

By
Alen Džubur Orcid logo ,
Alen Džubur
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Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina

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Malik Ejubović ,
Malik Ejubović
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Department of Internal Diseases, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina

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Fajkić Almir ,
Fajkić Almir

Department of Pathophysiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Amela Dervišević ,
Amela Dervišević

Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Azra Durak Nalbantić ,
Azra Durak Nalbantić

Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina

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Ajla Avdić Agić ,
Ajla Avdić Agić

Marien Hospital Witten, Witten, Germany

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Amela Džubur ,
Amela Džubur

Department of Public Health, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Mevludin Mekić
Mevludin Mekić

Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina

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Abstract

Aim
To assess triglyceride-to high-density lipoprotein cholesterol (TG/HDL)-C ratio in patients with acute coronary syndrome (ACS) and to verify its association with renal dysfunction.
Methods
A cross sectional study included 85 ACS patients divided in two groups with (ACS-RD) and without (ACS-nRD) presence of renal dysfunction, and 35 healthy subjects. Blood pressure, blood glucose, C-reactive protein, urea, creatinine, eGFR and serum lipids levels (total cholesterol, triglycerides, LDL-C, HDL-C) was measured in all participants. Based on the values of the measured lipid fractions TG/HDLc ratio was calculated.
Results
 Patients in ACS group had significantly lower HDL-C level (p<0.0005) but significantly higher TG level (p=0.046) and TG/HDL-C ratio (p<0.0005) than controls. There was a significant increase (p<0.0005) in TG/HDL-C ratio in ACS-RD group compared to ACS-nRD group. The ACS-RD group had significantly higher level of TG (p=0.001), serum urea (p=0.02) and creatinine (p<0.0005) compared to the ACS-nRD group. With a cutoff level of 1.135 TG/HDL-C ratio had a sensitivity of 77.6% and a specificity of 62.9% in distinguishing between ACS patients and healthy subjects. With cutoff value of 1.905 TG/HDL-C ratio had a sensitivity of 75.9% and a specificity of 78.6% in distinguishing between ACS patients with and without renal dysfunction.
Conclusion
This study confirms the reliability of the TG/HDL-C ratio as a simple, low cost and useful marker in distinguishing between patients with ACS and healthy subjects and ACS patients with and without renal dysfunction.

Keywords:

eGFR,
NSTEMI,
STEMI,
TG/HDL-C ratio

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