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Review paper

The role of aripiprazole in improvement of penile erection in schizophrenia patients with erectile dysfunction

By
Debby Handayati Harahap ,
Debby Handayati Harahap

Doctoral Program, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Carla Raymondalexas Marchira Orcid logo ,
Carla Raymondalexas Marchira
Contact Carla Raymondalexas Marchira

Department of Psychiatry, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Eti Nurwening Solikhah ,
Eti Nurwening Solikhah

Department of Pharmacology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Dicky Moch Rizal
Dicky Moch Rizal

Department of Physiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Abstract

Aim
To provide evidence regarding the effectiveness of aripiprazole in improving penile erection with a therapeutic strategy of
add-on or switching therapy in patients with schizophrenia.
Methods
PubMed, Cochrane, Clinical Key, ProQuest, EBSCOhost, and ScienceDirect were searched for any design study that
evaluated aripiprazole only or versus control (placebo or other antipsychotic) for erectile dysfunction in patients with schizophrenia. Three studies were identified and analysed from 295 initial articles. Data were then extracted from the studies and summarized descriptively.
Results
Two hundred ninety-five articles were screened, and three studies were identified and eventually selected. After the add-on or switching antipsychotic therapy to aripiprazole, the prevalence of erectile dysfunction and the score of erectile dysfunction or penile erection assessed by Nagoya and Sexual Function Questionnaire (NSFQ) and Arizona Sexual Experience Scale (ASEX) decreased.
Conclusion
Aripiprazole was effective to improve penile erectile function in patients with schizophrenia. The therapeutic strategy is
adjunctive treatment or switching therapy to aripiprazole.

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