Correlation of Ki67 expression with estrogen receptor (ER) and progesterone receptor (PR) status in breast cancer
Aim To determine whether Ki67 can be predicted through its correlation with the estrogen receptor (ER) and progesterone receptor (PR), to identify breast cancer subtypes and evaluate cell proliferation level and prognosis. Methods Patient clinical data were collected from medical records and pathology laboratory reports at Teaching Hospital, Facul...
By Dedy Hermansyah, Muhammad Al Anas, Kania Haura Chalisaturahmi, Mutiara Baitina, Karina Sugih Arto, Endi Taris Pasaribu
Association of Botulinum toxin treatment due to aesthetic corrections in the face with the level of happiness, anxiety and depression
Aim Any aesthetic procedure in the head and/or in the face might have an impact on psychological status of the treated participants. Aim of this study was to investigate whether Botulinum toxin treatment for aesthetic purpose in the face influences on the level of happiness, depression and anxiety. Methods This prospective cohort observational stu...
By Omar Suljagić, Emir Tupković, Kenana Ljuca, Faris Suljagić, Nadina Ljuca
Correlation Between Brain-Derived Neurotrophic Factor and Cognitive Function in Older Adults
Aim Brain Derived Neurotrophic Factor (BDNF) plays a crucial role in supporting neuronal survival, promoting neurogenesis, and enhancing synaptic plasticity, all of which are vital for cognitive health. Aim of this study was to investigate the relationship between BDNF levels and cognitive impairment in the elderly population. Methods This was a c...
By Effi Rohani Nuzul Sari, Fasihah Irfani Fitri, Aldy Safruddin Rambe, Taufik Ashar
Untargeted Urinary Metabolomic Profile of Isolated Chest Trauma Patients.
Untargeted Urinary Metabolomic Profile of Isolated Chest Trauma Patients. ABSTRACT: Aim To explore the untargeted urinary metabolomic biomarkers in isolated chest injury patients. Methods It was a prospective study for 1 year period including the patients of isolated chest trauma as per inclusion criteria. Day 0, 3, and 7 urine samples from pat...
By Irshad Ahmad, Debabrata Sircar, Madhur Uniyal, Mehvish Mukhtar, Ajay Kumar, Bhaskar Sarkar, Nilesh Jagne, Md Qamar Azam
A rare case of high-grade synovial sarcoma of the hindfoot
Aim: To report our personal experience in hindfoot reconstruction using an anterolateral thigh (ALT) free flap following radical resection of a high-grade synovial sarcoma. Methods The patient underwent clinical and imaging assessments, and a biopsy of the lesion confirmed the diagnosis of synovial sarcoma (SS) of the hindfoot. A multidisciplinary...
By Chiara Comisi, Camillo Fulchignoni, Antonio Mascio, Francesco Farine, Elisa Troiano, Nicola Mondanelli, Elisabetta Pataia, Giulio Maccauro, Carlo Perisano, Tommaso Greco
Comparison of coronary artery calcium scores between patients with and without type 2 diabetes
ABSTRACT Aim This study compared the extent of coronary artery calcification in patients with and without type 2 diabetes mellitus (T2DM) using Coronary Computed Tomography Angiography (CCTA). Methods This retrospective, observational cohort study included 107 patients who underwent CCTA at the Clinical Centre of the University of Sarajevo betwee...
By Mirza Babić, Zarina Babić Jušić, Sabina Prevljak, Fuad Zukić, Minela Bećirović, Amir Bećirović, Admir Abdić, Emir Bećirović
OPTIMIZATION OF ILLUMINA® NEXTERA™ XT LIBRARY PREPARATION FOR THE MITOCHONDRIAL GENOME SEQUENCING AND CONFIRMATORY SANGER SEQUENCING
Aim: Due to increasing use of mitochondrial DNA (mtDNA) sequencing in both forensic practice and clinical disease research, this study explores the optimization of the next-generation sequencing (NGS) method for whole mitochondrial genome analysis on the Illumina MiSeq platform. Methods: Initial attempts using pre-made commercial primers were unsuc...
By Nejira Handžić, Dino Pećar, Selma Durgut, Naida Mulahuseinović, Ivana Čeko, Adna Ašić, Mirza Izmirlija, Sabina Šegalo, Lana Salihefendić, Rijad Konjhodžić
Prognostic significance of CD163 expression in colorectal cancer stroma: a retrospective cohort study
Aim. Colorectal cancer (CRC) ranks among the leading causes of cancer-related mortality worldwide, with significant incidence and mortality rates recorded in Kazakhstan. CRC poses a substantial healthcare burden, prompting investigations into novel prognostic markers. Aim. This study investigates the prognostic significance of CD163 expression in ...
By Nauryzbay Imanbayev, Yerbolat Iztleuov, Arip Koyshybaev, Aigul Zhumasheva, Beibit Baizakov, Nurgul Kereyeva, Zhanna Satenova, Aigerim Imanbayeva, Anara Tulyayeva, Dinara Zholmukhamedova, Marzhan Aitmagambetova, Azamat Zharylgapov
The long-term follow up of patients with oligoarticular juvenile idiopathic arthritis: a single center experience.
AimTo evaluate the clinical course and outcomes of oligoarticular juvenile idiopathic arthritis(JIA) patients from 2003 to 2021, identifying factors linked to severe disease and complications. Methods We analyzed 208 oligoarticular JIA patients followed at Cerrahpaşa Medical School, using medical records. Continuous variables were compa...
By Aytan Aliyeva, Amra Adrovic, Fatih Aslak, Oya Koker, Mehmet Yildiz, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Impact of a Modified Discharge Program on Health Outcomes After Coronary Bypass Surgery: A Randomized Trial
Aim: This study examines the effects of implementing a modified Re-Engineered Discharge (RED) intervention on Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) and readmission rates 30 days after Coronary Artery Bypass Graft (CABG) surgery. Methods A randomized clinical trial was conducted with 104 participants who underwent...
By Hayat S. Abu Shaikha, Duaa AL Maghaireh, Mariam Kawafha, Jafar A. Alshraideh