Aim To investigate the role of hypoxia-preconditioned mesenchymal stem cells (H-MSCs) in preventing peritoneal adhesionby regulating IL-6 at days 6 and 12.Methods Twenty-four PAs rat model weighing 250 g to 300 g were randomly allocated into 4 groups: sham (Sh), control (C),H-MSCs treatment group at dose 1.5 x 106  (T1) and 3 x 106 (T2). To in...

By Adi Muradi Muhar, Agung Putra, Vito Mahendra Ekasaputra, Dewi Masyithah Darlan, Desiree Anggia Paramita, Iqbal Pahlevi Adeputra Nasution

Aim To investigate the effect of umbilical cord-derived mesenchymal stem cells (UC-MSCs) administration among liverfibrosis experimental rat model via the regulation of angiotensin II type 1 receptor (AT1R) and platelet-derived growth factor-β (PDGF-β) due to their therapeutic potential to replace liver transplantation for advanced liver ...

By Taufik Sungkar, Agung Putra, Dharma Lindarto, Rosita Juwita Sembiring

Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients.Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik GeneralHospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from C...

By Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf

Aim To analyse the ability of mesenchymal stem cells (MSCs) to regulate interleukin 6 (IL-6) and transforming growth factor (TGF-β) expression in vitro under co-culture conditions in human systemic lupus erythematosus (SLE). MethodThis study used a post-test group design that used peripheral blood mononuclear cells (PBMCs) from SLE patients at...

By Dewi Masyithah Darlan, Delfitri Munir, Nelva Karmila Jusuf, Agung Putra, Riyadh Ikhsan, Iffan Alif