Original article

Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience

Authors

Abstract

Aim: To compare the efficacy and safety of rotational atherectomy (RA) and modified balloons (MB) for calcified coronary lesion preparation.

Methods: This retrospective, single-centre study included 92 consecutive patients with angiographically significant coronary artery calcification (CAC) treated between September 2021 and December 2024. Patients were stratified according to lesion-preparation strategy: RA with the RotaPro system (Boston Scientific, Marlborough, MA, USA) (n = 42) or MB, including scoring or cutting balloons (n = 50). Patients treated with intravascular lithotripsy, super-high-pressure balloons, or non-compliant balloons alone were excluded. The primary endpoint was 1-year cardiovascular mortality, and the secondary endpoint was procedural success, defined as successful stent or drug-coated balloon implantation with <10% residual stenosis and final Thrombolysis in Myocardial Infarction grade 3 flow.

Results: Baseline age and renal function were comparable between groups. Microcatheter use was more frequent in the RA group (p<0.001), whereas smoking was more prevalent in the MB group (p=0.043). Fluoroscopy time was longer in the RA group (p<0.001). Cardiovascular mortality and procedural success did not differ significantly between groups.

Conclusion: In this real-world single-centre experience, RA and MB showed comparable feasibility and one-year clinical outcomes for the treatment of CAC. A lesion-specific approach integrating RA, MB and intravascular lithotripsy may optimise the management of calcified coronary lesions.

Keywords: coronary artery calcification, percutaneous coronary intervention, rotational atherectomy, treatment outcome

How to Cite: Mišković, D. , Gabaldo, K. , Silović, J. , Jakab, J. , Cvitkušić Lukenda, K. , Đanić Hadžibegović, A. , Milić, J. , Knežević Praveček, M. & Hadžibegović, I. (2026) “Comparison of rotational atherectomy and modified balloons for calcified lesion preparation: a single-centre experience”, Medicinski glasnik. 23(2). doi: https://doi.org/10.17392/medglas-2176-23-2

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