Original article

Local carboxymethyl-β-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study

Authors

• • Melika Dervišefendić Peljto dervisefendic@gmail.com Email Melika Dervišefendić Peljto. (compose email, opens in email app.) Melika Dervišefendić Peljto ORCID profile. (opens in new tab)
  • • Conceptualization
    • Data Curation
    • Formal Analysis
    • Investigation
    • Methodology
    • Writing - Original Draft
    • Writing - Review & Editing
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  • Primary Health Care Centre Gračanica, Gračanica, Bosnia and Herzegovina
• • Mahira Jahić
  • • Investigation
    • Methodology
    • Supervision
    • Writing - Review & Editing
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  • Gynaecological Centre “Dr. Mahira Jahić”, Tuzla, Bosnia and Herzegovina

Abstract

Aim: To evaluate the association between intravaginal therapy with carboxymethyl-β-glucan (CMBG) and polycarbophil and cytological regression of atypical squamous cells of undetermined significance (ASCUS) and cervical intraepithelial neoplasia grade 1 (CIN 1), compared with standard follow-up.

Methods: This prospective observational controlled study included 80 women aged 23–49 years with ASCUS or CIN 1. Forty patients received intravaginal CMBG/polycarbophil spray, and 40 were managed with standard follow-up. Allocation was based on clinical assessment and therapy availability, without randomisation. The primary outcome was cytological normalisation after 12 months, based on Papanicolaou smear results.

Results: After 12 months, abnormal cytology was observed in 4 (10.0%) patients in the treatment group and 18 (45.0%) in the control group (RR 0.22; 95% CI 0.08–0.60; p<0.001). Normal cytology was observed in 36 (90.0%) and 22 (55.0%) patients, respectively (p<0.001). Human papillomavirus (HPV) persistence was detected in 2 (5.0%) patients in the treatment group and 5 (12.5%) in the control group (p=0.432).

Conclusion: Intravaginal CMBG/polycarbophil therapy was associated with a higher rate of cytological normalisation than standard follow-up in women with ASCUS and CIN 1. 

Keywords: cervical intraepithelial neoplasia, human papillomavirus, vaginal therapy

How to Cite: Dervišefendić Peljto, M. & Jahić, M. (2026) “Local carboxymethyl-β-glucan and polycarbophil therapy is associated with regression of low-grade cervical cytological abnormalities: a prospective observational study”, Medicinski glasnik. 23(2). doi: https://doi.org/10.17392/medglas-2174-23-2