Original article

HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

Authors

• • Tina Christina Lumban Tobing
  • Universitas Sumatera Utara, Medan, Department of Child Health, School of Medicine, Indonesia
• • Teddy Ontoseno
  • Universitas Airlangga, Department of Child Health, School of Medicine, Indonesia
• • Sri Endah Rahayuningsih
  • Universitas Padjajaran, Department of Child Health, School of Medicine, Indonesia
• • Ratna Akbari Ganie
  • Universitas Sumatera Utara, Department of Clinical Pathology, Indonesia
• • Yahwardiah Siregar
  • Universitas Sumatera Utara, Department of Biochemistry, School of Medicine, Indonesia

Abstract

Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism's virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia.

Methods: An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software.

Results: A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15.

Conclusion: It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.

Keywords: cardiology, human leukocyte antigen, paediatric, RHD

How to Cite: Lumban Tobing, T. C. , Ontoseno, T. , Rahayuningsih, S. E. , Ganie, R. A. & Siregar, Y. (2019) “HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia”, Medicinski glasnik. 17(1). doi: https://doi.org/10.17392/1101-20