Allogenic platelet concentrates from umbilical cord blood for knee osteoarthritis: preliminary results

Vincenzo Caiaffa; Francesco Ippolito; Antonella Abate; Vittorio Nappi; Michele Santodirocco; Domenico Visceglie

doi:10.17392/1330-21

Original article

Allogenic platelet concentrates from umbilical cord blood for knee osteoarthritis: preliminary results

Authors

- Vincenzo Caiaffa Vincenzo Caiaffa ORCID profile. (opens in new tab)
- Di Venere Hospital Bari, Bari, Orthopaedic and Traumatology Unit, Italy
- Francesco Ippolito
- Di Venere Hospital Bari, Bari, Orthopaedic and Traumatology Unit, Italy
- Antonella Abate
- Di Venere Hospital Bari, Bari, Orthopaedic and Traumatology Unit, Italy
- Vittorio Nappi
- Di Venere Hospital Bari, Bari, Orthopaedic and Traumatology Unit, Italy
- Michele Santodirocco
- Apulia Cord Blood Bank Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
- Domenico Visceglie
- Di Venere Hospital Bari, Bari, Blood Transfusion Service, Italy

Abstract

Aim: To investigate the role of cordonal blood platelet-rich plasma (PRP) intra-articular injections for treating the patients with knee osteoarthritis in terms of procedure safety and clinical outcomes.

Methods: Twenty-five patients affected by knee osteoarthritis were enrolled and received one single intra-articular knee injection of umbilical cord PRP in a volume of 10 mL. A follow-up was investigated at time 0, 4, 8, 12 weeks and 6 months, evaluating clinical parameters and functional performances.

Results: No serious adverse events were identified. The paired ttest analysis showed a significant difference between baseline and each follow-up times for all clinical scales (p<0.05), with a significant improvement of clinical outcomes.

Conclusion: Allogeneic PRP can generate reliable therapeutic effect. The high content of tissue regenerative factors in cord blood platelets makes cordonal blood one of the ideal sources of PRP.

Keywords: allogenic, cordonal, osteoarthritis, platelet rich plasma

How to Cite: Caiaffa, V. , Ippolito, F. , Abate, A. , Nappi, V. , Santodirocco, M. & Visceglie, D. (2020) “Allogenic platelet concentrates from umbilical cord blood for knee osteoarthritis: preliminary results”, Medicinski glasnik. 18(1). doi: https://doi.org/10.17392/1330-21